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2 edition of prognostic effect of lipids on outcome of early-stage breast cancer. found in the catalog.

prognostic effect of lipids on outcome of early-stage breast cancer.

Mala Bahl

prognostic effect of lipids on outcome of early-stage breast cancer.

by Mala Bahl

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  • 6 Currently reading

Published .
Written in English


About the Edition

Early-stage breast cancer outcome is influenced by insulin and body mass index. These features are associated with dyslipidemia in the insulin resistance syndrome, but the contribution of lipids to breast cancer outcome is unclear. Using a cohort of 535 women without known hyperlipidemia or diabetes, the effect of lipids on recurrence and death was studied. Cox regression modeling was used to calculate hazard ratios with significance set at 0.025 (2-sided). Total cholesterol was correlated with age, and tumor grade. Triglycerides were correlated with insulin and BMI. At 8.7 years median follow-up, lipids were not associated with outcome in univariate analysis or when controlling for BMI and insulin. When controlling for tumor-related variables, triglycerides were not associated with outcome, but a trend towards significance was seen for recurrence (but not death) by total cholesterol (HR recurrence = 1.58, 4th:1st quartile, 2-sided P=0.043). This potential association should be explored in future studies.

The Physical Object
Pagination112 leaves.
Number of Pages112
ID Numbers
Open LibraryOL19217093M
ISBN 10049407308X

  Given the effects of obesity on cancer prognosis, one can ask if fat cells may have a role in leukemias as in other cancers. HER2-targeted therapies with trastuzumab improve survival of patients with HER2 over expressing metastatic breast cancer and early-stage breast cancer Drugging the lipid metabolism to improve treatment outcome. prognostic factor breast prognosis. FAQ. Medical Information Search. English. English Español Português Français Italiano Breast Cell Line, Tumor Lymph Nodes Axilla Neoplastic Cells, Circulating Tumor Cells, Cultured Bile Ducts, Intrahepatic Bone Marrow Lymphocytes, Tumor-Infiltrating MCF-7 Cells Mammary Glands, Human Milk, Human.

outcome prognosis, and can be a sensitive, but not spe- is to evaluate lipid profile and breast cancer risk with an emphasis on the prognosis value of lipid profiles in breast cancer patient. Continued. There are many treatments for invasive breast cancer. They include: Surgery.A lumpectomy is a surgical procedure in which a surgeon removes the cancer and a small area of healthy tissue.

Objective. To investigate the expression patterns and prognostic values of STEAP family members in the occurrence and development of breast cancer. Materials and Methods. The Human Protein Atlas was used to analyze the expression level of STEAPs in human normal tissues and malignant tumors. ONCOMINE datasets were analyzed for the comparison of the STEAPs levels between malignant .   The extent of breast cancer. The most common type of cancer among women is breast cancer, with over million women worldwide diagnosed with the disease annually, 1 and of these women, 35% will lose their lives to the disease. 2 Although breast cancer is mostly a disease of females, 1 in males may also develop the disease. 3.


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Prognostic effect of lipids on outcome of early-stage breast cancer by Mala Bahl Download PDF EPUB FB2

Background: The prognosis of women with early-stage BC is affected by certain metabolic factors, namely insulin and body mass index (BMI). Obesity and increased insulin are often seen together with dyslipidemia in the Insulin Resistance Syndrome, but the contribution of total cholesterol (TC) and triglycerides (TG) to BC outcome is unclear.

Methods: A cohort of women without known Cited by:   Purpose This study was performed to characterize the impact of obesity on the risk of breast cancer recurrence and death as a result of breast cancer or other causes in relation to adjuvant treatment.

Patients and Methods Information on body mass index (BMI) at diagnosis was available (35%) of 53, women treated for early-stage breast cancer in Denmark between and Cited by: Summary.

Purpose. The prognosis of women with early-stage breast cancer is influenced by insulin and body mass index (BMI). High levels of serum insulin and obesity often coexist with dyslipidemia in the insulin resistance syndrome (IRS), but the contribution of lipids to breast cancer outcome is unclear.

Purpose Vitamin D has been linked to breast cancer risk, but prognostic effects are unknown. Such effects are biologically plausible given the presence of vitamin D receptors in breast cancer cells, which act as nuclear transcription factors to regulate gene activity.

Patients and Methods The study was conducted in a prospective inception cohort of women with early breast cancer Cited by: Newly diagnosed breast cancer. The following are prognostic and predictive factors for breast cancer when it is first found and diagnosed.

Stage. The stage is the main prognostic factor for breast cancer. There is less risk that early stage breast cancer will come back (recur) so it has a more favourable prognosis.

M. Bahl, M. Ennis, I.F. Tannock, et lipids and outcome of early-stage breast cancer: results of a prospective cohort study Breast Cancer Cited by: 2. with breast cancer risk, though published results have been inconsistent. The aim of this study, therefore, is to find out the effect of lipids and obesity on breast cancer risk.

Most of the patients in our study were of high body weight due to varied reasons. Much preclinical and epidemiologic evidence supports anticancer effects of HMG-CoA reductase inhibitors (statins).

Epidemiologic evidence does not support an association between statin use and reduced breast cancer incidence, but does support a protective effect of statins—particularly simvastatin—on breast cancer argue that the current evidence base is sufficient to. The effect of tea consumption on breast cancer survival remained to be explored.

Meanwhile, green tea favorably facilitates lipid metabolisms in breast cancer survivors. This study aimed to examine the effect of tea consumption and the interactions with lipids on breast cancer survival.

A total of breast cancer patients were recruited between April and March. Prognostic value of chemotherapy-induced neutropenia in early-stage breast cancer Synchronous Chemo-radiation Can Reduce Local Recurrence in Early Stage Breast Cancer: Results of the SECRAB Trial Interaction of celecoxib with different anti-cancer drugs is antagonistic in breast but not in other cancer.

I Elomaa's 96 research works with 5, citations and 1, reads, including: Lactobacillus supplementation for diarrhoea related to chemotherapy of colorectal cancer: A randomised study.

Understanding Your Pathology Report: Breast Cancer. When your breast was biopsied, the samples taken were studied under the microscope by a specialized doctor with many years of training called a pathologist sends your doctor a.

A blood test combined with imaging tests detected tumors—some at an early stage—in women without a history of cancer or any symptoms, a recent study showed. The liquid biopsy, called CancerSEEK, also mistakenly indicated some women had cancer when additional testing determined they did not.

2. Obesity, Weight Gain, and Breast Cancer Outcome. At diagnosis, women with breast cancer who are overweight, obese, or have android body fat distribution experience increased risk of local recurrence, cancer-related death, and overall death by up to % [7, 8].Data have revealed that patients weighing over pounds at cancer diagnosis have inferior recurrence-free survival [].

Currently, it is used to assess the in vivo chemo sensitivity and biology of breast tumors and the long-term outcomes of breast cancer patients based on tumor responses [16,17].

Patients who fail to obtain the pathological complete response are candidates for adjuvant chemotherapies such as TDM1 or capecitabine [18,19]. CMML Prognostic Scoring Systems (from Spain and Dusseldorf) Assess risk of progression to AML and early mortality in CMML Diffuse Large B-Cell Lymphoma Prognosis (R-IPI) Determine prognosis in diffuse large B-cell lymphoma Follicular Lymphoma prognosis Determine prognosis in follicular lymphoma (FLIPI) Acute GVHD Grading Determine severity in.

1. Introduction. Ketogenic metabolic therapy (KMT) is emerging as a novel complementary or alternative therapeutic strategy for a broad range of malignant cancers including breast cancer [,,, ].Calorie restriction and low-carbohydrate high-fat ketogenic diets (KD) reduce the glucose needed to drive the Warburg effect while also elevating ketone bodies [10,13].

Breast cancer treatments include surgery, chemotherapy, radiation, hormonal therapies, and more. Treatments can cause a variety of side effects, from nausea and hot flashes to hair loss and joint pain. Learn more about breast cancer treatments and how to manage their side effects.

Breast cancer is the most common solid organ cancer diagnosed in women worldwide. In the United States, one in eight women will develop breast cancer in her lifetime, and, inthere were million breast cancer survivors living in the United States [].Approximately 75% of women diagnosed with early stage breast cancer have estrogen receptor–positive (ER +) disease, and virtually all.

PURPOSE: Insulin, a member of a family of growth factors that includes insulin-like growth factor (IGF)-I and IGF-II, exerts mitogenic effects on normal and malignant breast epithelial cells, acting via insulin and IGF-I receptors.

Because of this and because of its recognized association with obesity, an adverse prognostic factor in breast cancer, we examined the prognostic associations of. The association of lipids and lipoproteins with ovarian and breast cancer is exclusively assessed in some previous studies.

12,13 In some studies, it has been shown that a higher intake of dietary lipids, systemic lipid metabolism malfunction, and abnormal serum lipid levels are related to ovarian cancer. Over-expression of some lipid metabolic.TNBC is considered more aggressive with a poorer prognosis than other types of breast cancer, mainly because there are fewer targeted medicines that treat triple-negative breast cancer.

Systemic effects of adiposity are believed to be implicated in breast cancer development and aggressiveness, and may involve breast fat [ 19 ].

Thorac Cancer. Jul doi: / Online ahead of CTDeltex-1 (DTX1) is a negative regulator of the Notch signaling pathway. Here, we investigated the clinical effect of DTX1 rsA > G, which is associated with better prognosis in patients with early-stage non-small cell lung cancer (NSCLC), in